Author:

Keywords:

systemic lupus-erythematosus, filament-aggregating protein, human epidermis filaggrin, antiperinuclear factor, antikeratin antibodies, induced apoptosis, synovial-fluid, plasma-cells, recent-onset, disease, Science & Technology, Life Sciences & Biomedicine, Rheumatology, SYSTEMIC LUPUS-ERYTHEMATOSUS, FILAMENT-AGGREGATING PROTEIN, HUMAN EPIDERMIS FILAGGRIN, ANTIPERINUCLEAR FACTOR, ANTIKERATIN ANTIBODIES, INDUCED APOPTOSIS, SYNOVIAL-FLUID, PLASMA-CELLS, RECENT-ONSET, DISEASE, Amino Acid Sequence, Arthritis, Rheumatoid, Autoantibodies, Citrulline, Cross Reactions, Epitope Mapping, Filaggrin Proteins, Humans, Immunoassay, Immunoblotting, Immunodominant Epitopes, Intermediate Filament Proteins, Models, Molecular, Molecular Sequence Data, Peptide Fragments, Recombinant Proteins, Reproducibility of Results

Abstract:

Objective. To identify immunodominant epitopes in natural filaggrin that are reactive with antifilaggrin autoantibodies (AFA) in the sera of patients with rheumatoid arthritis (RA) and to explore their use in a diagnostic assay format.