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Title: Continuous inhibition of serotonin-induced platelet-aggregation during chronic ketanserin administration to man can be detected after plasma-ph control
Authors: Arnout, Jozef ×
Vanrusselt, Marleen
Deckmyn, Hans
Vermylen, Jozef #
Issue Date: 1987
Publisher: Karger
Series Title: Haemostasis vol:17 issue:6 pages:344-348
Abstract: Ketanserin is a well-known serotonin S2 receptor antagonist but its capacity to inhibit serotonin-induced aggregation ex vivo during chronic administration has been a matter of debate. In vitro evidence is presented that the inhibitory capacity of ketanserin is lowered by increasing plasma pH. Since the pH of plasma kept at the open air increases with time, we studied the effect of chronic administered ketanserin on serotonin-induced platelet aggregation in plasma kept at a lowered pH of 7.70, by replacing the air with 95% O2-5% CO2. Using this slightly modified technique, we could, in contrast to our previous studies, observe a complete inhibition of the serotonin-induced aggregation throughout the ketanserin treatment period.
ISSN: 0301-0147
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Cellular Medicine - miscellaneous (-)
Molecular and Vascular Biology
Chemistry, Campus Kulak Kortrijk
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
Biomedical Sciences Group Management - miscellaneous
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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