Title: Factor XI/ADAMTS13 complexes are quantitatively insignificant in human plasma
Authors: Anderson, Patricia J ×
Gailani, David
Feys, Hendrik
Gao, Weiqiang
Majerus, Elaine M
Vanhoorelbeke, Karen
Sadler, J. Evan #
Issue Date: Oct-2007
Publisher: Ferrata storti foundation
Series Title: Haematologica vol:92 issue:10 pages:1419-1422
Abstract: Reportedly, complexes between factor XI and ADAMTS13 are detected with a commercial ADAMTS13/FXI ELISA kit in plasma and are decreased in thrombotic thrombocytopenic purpura (TTP). Using this kit, control and TTP patient plasma contained varying amounts of signal (25-670% of a reference plasma) but no signal was observed for mixtures of recombinant enzymes, suggesting little interaction. ADAMTS13/FXI complexes were undetectable by immunoprecipitation or gel filtration chromatography in control plasma or mixtures of recombinant proteins. These results suggest that ADAMTS13/FXI complexes are insignificant in plasma and unlikely to affect the function of either protein during normal hemostasis or in TTP.
ISSN: 0390-6078
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Chemistry, Campus Kulak Kortrijk
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
× corresponding author
# (joint) last author

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