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Title: Surface functionalization of magnetoliposomes in view of improving iron oxide-based magnetic resonance imaging contrast agents: anchoring of gadolinium ions to a lipophilic chelate
Authors: De Cuyper, Marcel ×
Soenen, Stefaan
Coenegrachts, Kenneth
Ter Beek, Leon #
Issue Date: 15-Jul-2007
Publisher: Elsevier
Series Title: Analytical Biochemistry vol:367 issue:2 pages:266-273
Abstract: Small unilamellar phospholipid vesicles containing the phosphatidylethanolamine-diethylene triamine pentaacetic acid (PE-DTPA) conjugate as one of the building stones were constructed. The ability of these colloids to complex gadolinium(III) ions at the surface of both the inner and outer bilayer shells was verified using a colorimetric method with Arsenazo III as a dye indicator. On incubation of these functionalized vesicles with magnetoliposomes (MLs, nanometer-sized magnetite cores encapsulated in a phospholipid bilayer), PE-DTPA percolates into the ML coat. The PE-DTPA content could be fine-tuned by varying the conjugate concentration in the donor vesicles. In the experimental conditions applied, up to 500 Gd(3+) ions were immobilized per ML colloid. The resulting ML-Gd(3+) complexes might have great potential, for example, as a novel magnetic resonance imaging contrast agent.
ISSN: 0003-2697
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
Faculty of Medicine, Campus Kulak Kortrijk
× corresponding author
# (joint) last author

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