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Title: Outcome after 'curative' surgery for carcinoma of the lower third of the rectum
Authors: Topal, Baki ×
Penninckx, Freddy
Kaufman, L
Filez, Ludo
Aerts, Raymond
Ectors, Nadine
Kerremans, Raymond #
Issue Date: Sep-1998
Series Title: British Journal of Surgery vol:85 issue:8 pages:1118-20
Abstract: BACKGROUND: Controversy exists about the optimal surgical resection for lower third rectal carcinoma. The aim of this retrospective study was to analyse whether the type of surgery is a significant predictor of outcome after curative surgery alone. METHODS: Eighty-two consecutive patients underwent abdominoperineal rectum excision (APRE, 41 patients) or sphincter-saving operation (SSO, 41 patients) for adenocarcinoma at 3.5-7.5 cm from the anal margin. Cox proportional hazards technique with univariate and corrected (multivariate) analyses and the Kaplan-Meier life-table method were used to evaluate the data. RESULTS: Tumour wall penetration and lymph node involvement, but not the tumour level or the type of surgery, were found to be significant predictors of outcome. The local recurrence rate at 1, 2 and 5 years was 10, 22 and 26 per cent respectively after APRE, and 5, 13 and 21 per cent after SSO. The disease-free survival rate at 1, 2 and 5 years was 85, 67 and 58 per cent respectively after APRE, and 88, 78 and 62 per cent after SSO. CONCLUSION: Tumour-related factors are significant predictors of outcome. The type of surgery (APRE or SSO) did not seem to be a significant variable in this non-randomized study.
ISSN: 0007-1323
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Abdominal Surgical Oncology
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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