Title: Non-invasive grading of brain tumours using dynamic amino acid PET imaging : does it work for (11)C-Methionine?
Authors: Moulin-Romsée, Gérard ×
D'Hondt, Eduard
de Groot, Tjibbe
Goffin, Jan
Sciot, Raphael
Mortelmans, Luc
Menten, Johan
Bormans, Guy
Van Laere, Koen #
Issue Date: Dec-2007
Series Title: European Journal of Nuclear Medicine and Molecular Imaging vol:34 issue:12 pages:2082-2087
Abstract: BACKGROUND: Static imaging of amino acids does not allow differentiation of low versus high grade brain tumours. It has been shown that dynamic imaging of the amino acid analogue (18)F-fluoroethyltyrosine (FET) can achieve this goal. In many centres, (11)C-methionine (MET) is used for tumour imaging, but no clinical studies on the use of dynamic scanning for grading have been performed. METHODS: Thirty-four patients with primary brain glioma and histopathological confirmation were retrospectively studied using 40 min dynamic MET-PET with 220 MBq 11C-methionine. In relation to histopathological grading, various metabolic indices and temporal parameters as documented by Poepperl et al. (JNM 2006;47:393-403) were analyzed. RESULTS: None of the evaluated static or temporal parameters allowed discrimination between high and low grade tumours. On average, low grade tumours showed washout after the initial uptake maximum, while both increases and decreases were seen for high grade tumours. Only the relative early versus late uptake ratio showed a trend towards significance (-0.16 +/- 0.17 for low grade versus 0.01 +/- 0.25 for high grade; p = 0.07). CONCLUSION: Unlike FET-PET, the uptake characteristics of MET-PET do not allow classification of low and high grade tumours on an individual patient basis. Since literature data indicate that both tracers have a similar performance regarding biopsy location, tumour delineation, and detection of recurrence, FET-PET should be advocated over MET-PET as its uptake mechanism also allows noninvasive grading in glioma.
ISSN: 1619-7070
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Radiotherapy
Nuclear Medicine & Molecular Imaging
Research Group Experimental Neurosurgery and Neuroanatomy
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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