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Title: Analytical performance and clinical utility of the INNOTEST (R) PHOSPHO-TAU((181P)) assay for discrimination between Alzheimer's disease and dementia with Lewy bodies
Authors: Vanderstichele, Hugo ×
De Vreese, Karen
Blennow, Kaj
Andreasen, Niels
Sindic, Christian
Ivanoiu, Adrian
Hampel, Harald
Bürger, Katharina
Parnetti, Lucilla
Lanari, Alessia
Padovani, Allesandro
DiLuca, Monica
Bläser, Miriam
Olsson, Annika Ohrfelt
Pottel, Hans
Hulstaert, Frank
Vanmechelen, Eugeen #
Issue Date: 2006
Series Title: Clinical chemistry and laboratory medicine : CCLM / FESCC vol:44 issue:12 pages:1472-1480
Abstract: BACKGROUND: Total tau (T-tau) and beta-amyloid((1-42)) (Abeta(1-42)) levels in cerebrospinal fluid (CSF) can differentiate Alzheimer's disease (AD) from normal aging or depressive pseudo-dementia. Differential diagnosis from dementia with Lewy bodies (DLB) in clinical settings is difficult. METHODS: The analytical performance of the INNOTEST PHOSPHO-TAU(181P) assay was validated in terms of selectivity, sensitivity, specificity, precision, robustness, and stability. Clinical utility of the assay alone, or combined with T-tau and Abeta(1-42), for discrimination of AD (n=94) from patients suffering from DLB (n=60) or from age-matched control subjects (CS) (n=60) was assessed in a multicenter study. RESULTS: CSF concentrations of tau phosphorylated at threonine 181 (P-tau(181P)) in AD was significantly higher than in DLB and CS. Discriminant analysis, a classification tree, and logistic regression showed that P-tau(181P) was the most statistically significant single variable of the three biomarkers for discrimination between AD and DLB. CONCLUSIONS: P-tau(181P) quantification is a robust and reliable assay that may be useful in discriminating AD from DLB.
URI: 
ISSN: 1434-6621
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine, Campus Kulak Kortrijk
× corresponding author
# (joint) last author

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