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Title: Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
Authors: van Es, Michael A ×
van Vught, Paul W J
Blauw, Hylke M
Franke, Lude
Saris, Christiaan G J
Van Den Bosch, Ludo
de Jong, Sonja W
de Jong, Vianney
Baas, Frank
van't Slot, Ruben
Lemmens, Robin
Schelhaas, Helenius J
Birve, Anna
Sleegers, Kristel
Van Broeckhoven, Christine
Schymick, Jennifer C
Traynor, Bryan J
Wokke, John H J
Wijmenga, Cisca
Robberecht, Wim
Andersen, Peter M
Veldink, Jan H
Ophoff, Roel A
van den Berg, Leonard H #
Issue Date: Jan-2008
Series Title: Nature Genetics vol:40 issue:1 pages:29-31
Abstract: We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
URI: 
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Laboratory for Neurobiology (Vesalius Research Center)
× corresponding author
# (joint) last author

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