Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
van Es, Michael A × van Vught, Paul W J Blauw, Hylke M Franke, Lude Saris, Christiaan G J Van Den Bosch, Ludo de Jong, Sonja W de Jong, Vianney Baas, Frank van't Slot, Ruben Lemmens, Robin Schelhaas, Helenius J Birve, Anna Sleegers, Kristel Van Broeckhoven, Christine Schymick, Jennifer C Traynor, Bryan J Wokke, John H J Wijmenga, Cisca Robberecht, Wim Andersen, Peter M Veldink, Jan H Ophoff, Roel A van den Berg, Leonard H #
Nature Genetics vol:40 issue:1 pages:29-31
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.