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Title: The 'artificial high pressure zone'. A non-invasive method to study in man the effect of the inhibitory innervation to the oesophagus. Validation study using a combined manometric--barostat technique
Authors: Sifrim, Daniel ×
Janssens, J #
Issue Date: Feb-1999
Series Title: European journal of gastroenterology & hepatology vol:11 issue:2 pages:165-9
Abstract: OBJECTIVE: We previously developed a technique to study the effect of inhibitory innervation in the human oesophageal body, by creating an artificial high pressure zone (artificial HPZ) using an intra-oesophageal balloon. Swallowing provokes a fall in pressure in the artificial HPZ that precedes the peristaltic contraction. We aimed to prove that the swallow-induced fall in pressure in the artificial HPZ is due to relaxation of a segmental tonic contraction of the oesophageal wall at that level. METHODS: Studies were performed in five healthy subjects. Oesophageal pressures were measured at 5, 10 and 15 cm above the lower oesophageal sphincter. A rubber balloon opposite the middle pressure sensor was used to induce the artificial HPZ. A barostat bag was glued to the opposite side of the balloon. The pressure in the barostat bag was pre-set at 8 mmHg below the pressure measured in the artificial HPZ. We studied deglutition-induced variations in the barostat bag volume after single and multiple swallows. RESULTS: Immediately after single swallows and during multiple swallows, we observed a fall in pressure in the artificial HPZ and a significant increase in the barostat bag volume (254+/-67%) from 0.99 (0.37-1.93) to 3.74 (1.91-4.34) (P = 0.005) denoting oesophageal wall relaxation. CONCLUSION: The swallow-induced fall in pressure in the artificial HPZ represents a real relaxation of a segmental tonic contraction of the oesophageal wall due to deglutitive inhibition. The oesophageal artificial HPZ is a simple method that can be used to study inhibitory phenomena in the body of the human oesophagus.
ISSN: 0954-691X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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