Title: Decreased lamina propria effector cell responsiveness to interleukin-10 in ileal Crohn's disease
Authors: Colpaert, Stefaan ×
Vanstraelen, Kathleen
Liu, Zhanju
Penninckx, Freddy
Geboes, Karel
Rutgeerts, Paul
Ceuppens, Jan #
Issue Date: Jan-2002
Publisher: Academic Press
Series Title: Clinical Immunology vol:102 issue:1 pages:68-76
Abstract: We investigated whether a lack of IL-10 production or responsiveness could be involved in Crohn's disease pathogenesis. Lamina propria mononuclear cells, isolated from the ilea of Crohn's disease patients (n = 16) and controls (n = 13), were activated with anti-CD3 mAb in the presence of CD80 transfectants or LPS +/- IFN-gamma. No evidence for deficient IL-10 production by either T cells or macrophages in Crohn's disease was found. However, the efficacy of rhIL-10 to down-regulate IFN-gamma and especially TNF production in cell cultures from the involved tissues of Crohn's disease patients was poor, and the use of an anti-IL-10R mAb even provided evidence for proinflammatory effects of IL-10. This lack of IL-10 effect possibly results from IL-12 activity. We conclude that IL-10 exhibits poor anti- and even potential proinflammatory effects on ileal Crohn's disease lamina propria. These data might explain the lack of therapeutic efficacy when IL-10 is given to Crohn's disease patients.
ISSN: 1521-6616
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Abdominal Surgical Oncology
Translational Cell & Tissue Research
Translational Research in GastroIntestinal Disorders
Laboratory of Clinical Immunology
× corresponding author
# (joint) last author

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