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Title: Ex vivo experiment on radiofrequency liver ablation with saline infusion through a screw-tip cannulated electrode
Authors: Miao, Yi ×
Ni, Yicheng
Mulier, S
Wang, K
Hoey, M F
Mulier, P
Penninckx, Freddy
Yu, Jie
De Scheerder, Ivan
Baert, A L
Marchal, Guy #
Issue Date: Sep-1997
Series Title: The Journal of surgical research vol:71 issue:1 pages:19-24
Abstract: PURPOSE: To investigate whether radiofrequency (RF) therapy with hypertonic saline infusion through a hollow screw-tip electrode can cause a lesion size suitable for liver tumor ablation. MATERIALS AND METHODS: RF tissue ablation of 180 sites was performed by using a hollow screw-tip electrode in 40 freshly excised swine livers. Under both power and temperature control modes, the ablation effects with and without various regimes of 5% hypertonic saline (1 ml/min) prior to and/or during the procedure were compared by measuring the size of lesions at dissection and confirmed by T1 and T2 weighted magnetic resonance (MR) imaging. RESULTS: The maximal lesion diameter of 5.5 cm was reached at 30 W with saline infusion 1 min prior to and during 12 min of ablation. The smaller sizes (P < 0.01) between 0.3 and 2.5 cm in diameter were met with noninfusion or preinfusion-only groups. The RF ablation lesions appeared as hyper- and hypointense areas on T1 and T2 MR images, respectively. CONCLUSIONS: RF ablation in combination with present hollow screw-tip electrode and saline infusion allows for necrotic development of suitable size for liver tumor ablation. Such ablated lesions can be visualized with MR imaging.
ISSN: 0022-4804
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Abdominal Surgical Oncology
Theragnostic Laboratory (+)
× corresponding author
# (joint) last author

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