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Title: Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans
Authors: Ban, Maria * ×
Booth, David *
Heard, Robert *
Stewart, Graeme *
Goris, An *
Vandenbroeck, Koen *
Dubois, Bénédicte *
Laaksonen, Mikko *
Ilonen, Jorma *
Alizadeh, Mehdi *
Edan, Gilles *
Babron, Marie Claude *
Brassat, David *
Clanet, Michael *
Cournu-Rebeix, Isabelle *
Fontaine, Bertrand *
Semana, Gilbert *
Goedde, Rene *
Epplen, Jorg *
Weber, Alexandra *
Infante-Duarte, Carmen *
Zipp, Frauke *
Rajda, Cecilia *
Bencsik, Krisztina *
Vecsei, Laszlo *
Heggarty, Shirley *
Graham, Colin *
Hawkins, Stanley *
Liguori, Maria *
Momigliano-Richiardi, Patricia *
Caputo, Domenico *
Grimaldi, Luigi M. E *
Leone, Maurizio *
Massacesi, Luca *
Milanese, Clara *
Salvetti, Marco *
Savettieri, Giovani *
Trojano, Maria *
Bielecki, Bartosz *
Mycko, Marcin P *
Selmaj, Krzysztof *
Santos, Monica *
Maciel, Patricia *
Pereira, Clara *
Silva, Ana *
Silva, Berta Martins *
Coraddu, Francesca *
Marrosu, Maria Giovanna *
Akesson, Eva *
Hillert, Jan *
Datta, Pameli *
Oturai, Annette *
Harbo, Hanne F *
Spurkland, Anne *
Goertsches, Robert *
Villoslada, Pablo *
Eraksoy, Mefkure *
Hensiek, Anke *
Compston, Alastair *
Setakis, Efrosini *
Gray, Julia *
Yeo, Tai Wan *
Sawcer, Stephen * #
Issue Date: Sep-2006
Publisher: Elsevier science bv
Series Title: Journal of neuroimmunology vol:179 issue:1-2 pages:108-116
Abstract: By combining all the data available from the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) project, we have been able to identify 17 microsatellite markers showing consistent evidence for apparent association. As might be expected five of these markers map within the Major Histocompatibility Complex (MHC) and are in LD with HLA-DRB1. Individual genotyping of the 12 non-MHC markers confirmed association for three of them--D11S1986, D19S552 and D20S894. Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1.
ISSN: 0165-5728
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Laboratory for Neuroimmunology
* (joint) first author
× corresponding author
# (joint) last author

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