Title: Aggressive and indolent non-Hodgkin's lymphoma: response assessment by integrated international workshop criteria
Authors: Brepoels, Lieselot ×
Stroobants, Sigrid
De Wever, Walter
Spaepen, Karoline
Vandenberghe, Peter
Thomas, José
Uyttebroeck, Anne
Mortelmans, Luc
Peeters, Christiane
Verhoef, Gregor #
Issue Date: Aug-2007
Publisher: Harwood Academic Publishers
Series Title: Leukemia & Lymphoma vol:48 issue:8 pages:1522-1530
Abstract: Until recently, response assessment in patients with lymphoma was primarily performed by computed tomography (CT). Based on CT, International Workshop Criteria (IWC) were developed and widely used. Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) is a more sensitive and specific imaging technique for the detection of residual disease in lymphoma, and Revised Integrated International Workshop Criteria (IWC + PET) were recently proposed by the members of the International Harmonization Project (IHP), which combine both imaging techniques. We determined whether these new IWC + PET-criteria, can more accurately predict outcome compared to IWC-criteria in aggressive and indolent non-Hodgkin's lymphoma (NHL), and therefore correlated IWC and IWC + PET response with time-to-next-treatment (TNT) in 69 patients with NHL. We demonstrated that IWC + PET-guidelines are highly recommended over IWC-guidelines for patients with potentially-curable and routinely FDG-avid lymphoma. In contrast, no additional value of IWC + PET was demonstrated in a small group of patients with incurable histological subtypes.
ISSN: 1042-8194
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Nuclear Medicine & Molecular Imaging
Department of Oncology - miscellaneous
Translational Cell & Tissue Research
Department of Human Genetics - miscellaneous
Organ Systems (+)
× corresponding author
# (joint) last author

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