Title: The clinical significance of activated lymphocytes in patients with myelodysplastic syndromes: A single centre study of 131 patients
Authors: Meers, Stef ×
Vandenberghe, Peter
Boogaerts, Marc
Verhoef, Gregor
Delforge, Michel #
Issue Date: Jul-2008
Publisher: Pergamon Press
Series Title: Leukemia Research vol:32 issue:7 pages:1026-1035
Abstract: We studied the immune compartment in patients with myelodysplastic syndromes. We show increased surface expression of activation markers (HLA-DR(+), CD57(+), CD28(-), CD62L(-)) on T lymphocytes in blood and bone marrow (n=131). T cell activation was not restricted to any relevant clinical subgroup (FAB, IPSS, cytogenetics) and did not correlate with blood counts or need for treatment. In vitro clonogenic growth of marrow mononuclear cells (n=18) was not influenced by T cells expressing these markers. In addition, using X-chromosome inactivation analysis (n=12) we demonstrate clonal involvement of NK and B cells in half of these patients. We conclude that although activated T lymphocytes can be found in MDS, their role in disease pathogenesis remains unclear in the majority of patients.
ISSN: 0145-2126
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Clinical Residents Medicine
Hematology Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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