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Title: Long-term persistence of vaccine-induced mumps antibodies in university students, Belgium
Authors: Vandermeulen, Corinne ×
Roelants, Mathieu
Leroux-Roels, Geert
Van Damme, Pierre
Hoppenbrouwers, Karel #
Issue Date: May-2005
Host Document: Abstract book pages:105
Conference: Meeting of the European Society for Pediatric Infectious diseases (ESPID) edition:23rd meeting location:Valencia, Spain date:18-20 may 2005
Abstract: Background and aims: Previous Belgian recommendations for immunization included measles-mumps-rubella (MMR)-vaccine at 15 months and 10-12 years of age. In 1999, estimated MMR1-vaccination coverage at 24 months of age was 83.4%, and own research showed a MMR-vaccination coverage of 89.7% (1 dose) in >12 year olds. Several mumps outbreaks in schools have been reported recently.
The aim was to evaluate long-term persistence of vaccine-induced antibodies against mumps.
Methods: After written informed consent students vaccinated against hepatitis A+B were invited to have a blood sample taken to determine antibody titers against mumps. For all students certified mumps-vaccination (at least one dose) was obtained through vaccination cards and school medical records.
Results: Serum samples of 128 students were analyzed, of whom 60.9% had certified proof of two mumps-vaccinations.

Table 1: Antibody status of students (%) according to number of mumps-vaccines.
number mumps-doses Mumps antibody status
Negative Equivocal Positive
(<230) (230-529) (530)
1 (n=50) 22.0 18.0 60.0
2 (n=78) 15.4 20.5 64.1

In a large fraction of students protective antibody titers against mumps cannot be ascertained despite vaccination. Only 62.5% of the students displayed protective antibody levels.
The antibody status of both student groups was remarkably similar if students had received only one dose 17-20 years ago, or received two doses of which the second one was administered only 8-9 years ago (table 1, p=0.6).
Conclusion: A substantial part of young adults lost their mumps antibodies, despite administration of 1-2 doses of mumps-vaccine. Assessing whether circulating antibody levels are an adequate marker of long-term protection becomes therefore increasingly important. Moreover research should be oriented to cellular immunity in those who lost anti-mumps antibodies years after vaccination.
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Youth Health (-)
Environment and Health - miscellaneous
× corresponding author
# (joint) last author

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