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Title: Effect of azithromycin on bronchiectasis and pulmonary function in a heart-lung transplant patient with severe chronic allograft dysfunction: a case report
Authors: Verleden, Geert ×
Dupont, Lieven
Vanhaecke, Johan
Daenen, Willem
Van Raemdonck, Dirk #
Issue Date: Aug-2005
Publisher: Mosby-Year Book
Series Title: The Journal of Heart and Lung Transplantation vol:24 issue:8 pages:1155-8
Abstract: Azithromycin has been shown to be beneficial in several diseases with chronic neutrophilic inflammation of the airways, such as cystic fibrosis and bronchiolitis obliterans syndrome (BOS) after lung transplantation. Up to now, however, its healing effect on bronchiectasis has never been demonstrated. We report a heart-lung transplant patient who developed chronic rejection (BOS stage 3) with the appearance of gross bronchiectasis on a spiral computed tomography (CT) chest scan. Within 2 weeks after starting azithromycin, the patient's forced expiratory volume in 1 second increased significantly and a repeat spiral CT chest scan 5 months later, showed a major improvement of the bronchiectasis. This case report illustrates that bronchiectasis may greatly improve after treatment with azithromycin and no longer needs to be considered an endstage finding in patients with severe BOS.
ISSN: 1053-2498
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
Clinical Cardiac Surgery
Thoracic Surgery
× corresponding author
# (joint) last author

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