Title: The visualization of hepatic vasculature by X-ray micro-computed tomography
Authors: Ananda, Shalini ×
Marsden, Valerie
Vekemans, Katrien
Korkmaz, Emine
Tsafnat, Naomi
Soon, Lilian
Jones, Allan
Braet, Filip #
Issue Date: Sep-2006
Series Title: Journal of electron microscopy vol:55 issue:3 pages:151-5
Abstract: In this study, X-ray micro-computed tomography (CT) was used to reconstruct the fine structure macro- and microvasculature in three dimensions in contrast-enhanced rat liver samples. The subsequent application in the experimental CC531s colorectal cancer model was concurrent with results obtained from confocal microscopy in earlier studies. The en bloc stains osmium tetroxide in combination with uranyl acetate provided an excellent contrasting result for hepatic tissue after a trial of several contrasting agents. X-ray micro-CT allowed us to image the large blood vessels together with the branching sinusoids of hepatic tissue in three dimensions. Furthermore, interruption of the microvasculature was noted when rats were injected with CC531s colorectal cancer cells indicating the presence of hepatic metastases.
ISSN: 0022-0744
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Abdominal Transplantation
× corresponding author
# (joint) last author

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