Title: Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff
Authors: Nakase, Takanobu ×
Sugamoto, Kazuomi
Miyamoto, Takashi
Tsumaki, Noriyuki
Luyten, Frank
Inui, Hiroaki
Myoui, Akira
Tomita, Tetsuya
Yoshikawa, Hideki #
Issue Date: May-2002
Series Title: Clinical Orthopaedics and Related Research issue:399 pages:140-5
Abstract: Localization and expression of cartilage-derived morphogenetic protein-1 in tissues of torn rotator cuff tendons were examined by in situ hybridization and immunohistochemical analysis. Histologic findings of torn rotator cuff tendons showed that active cells synthesizing the alpha-1 chain of collagen Type I messenger ribonucleic acid were localized predominantly in the torn edge and in the bursa side rather than in the joint side, and scarcely localized in a site distant from the torn edge. Cartilage-derived morphogenetic protein-1 had a similar distribution as the alpha-1 chain of collagen Type I. The current findings provide the first observational evidence that cartilage-derived morphogenetic protein-1 was activated specifically at the site of the torn rotator cuff tendon. The current findings suggest that the cells in the torn rotator cuffs are capable of synthesizing cartilage-derived morphogenetic protein-1, one of the known essential factors for tendon formation.
ISSN: 0009-921X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Rheumatology Section (-)
× corresponding author
# (joint) last author

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