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Title: Clinical trial of brinase and anticoagulants as a method of treatment for advanced limb ischemia
Authors: Verhaeghe, Raymond ×
Verstraete, Marc
Schetz, J
Vanhove, P
Suy, R
Vermylen, Jozef #
Issue Date: Jan-1980
Series Title: European journal of clinical pharmacology vol:16 issue:3 pages:165-70
Abstract: A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused s significant increase in calf and ankle pressure index. At six months follow-up, the clinical results were statistically significant in favour of Brinase when all patients were considered, but not if 10 patients with Buerger's disease were omitted from the analysis. Patients treated with a combination of Brinase and coumarins had a better clinical outcome than patients receiving either treatment on its own.
ISSN: 0031-6970
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine - miscellaneous
Molecular and Vascular Biology
× corresponding author
# (joint) last author

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