Title: Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates
Authors: Paul, G C ×
De Clercq, Erik
Pannecouque, Christophe
Witvrouw, Myriam
Loftus, T L
Turpin, J A
Buckheit, R W
Cushman, M #
Issue Date: Sep-2000
Series Title: Bioorganic & medicinal chemistry letters vol:10 issue:18 pages:2149-52
Abstract: The binding of the anti-HIV agent cosalane to CD4 is thought to involve ionic interactions of negatively charged carboxylates of the ligand with positively charged residues on the surface of the protein. An investigation of the optimal anion distances for anti-HIV activity in a series of cosalane tetracarboxylate analogues has been completed, and maximal activity results when the two proximal and the two distal carboxylates are separated by eight atoms.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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