Title: Effects of the CLIP fragment ACTH 20-24 on the duration of REM sleep episodes
Authors: Wetzel, W ×
Wagner, T
Vogel, D
Demuth, HU
Balschun, Detlef #
Issue Date: Feb-1997
Publisher: Churchill livingstone
Series Title: Neuropeptides vol:31 issue:1 pages:41-45
Abstract: Substances acting upon rapid eye movement (REM) sleep or paradoxical sleep (PS) can affect the number and/or the duration of PS episodes. In the present study, we investigated the effects of the proopiomelanocortin-derived peptide CLIP (corticotropin-like intermediate robe peptide, ACTH 18-39) and its N-terminal fragments ACTH 18-24 and ACTH 20-24 on the duration of PS episodes in rats. Intracerebroventricular injection of ACTH 20-24 caused a pronounced prolongation of PS episodes (up to 7 min duration, never seen under baseline conditions), whereas ACTH 18-24 acted in a similar way but without reaching statistical significance. We suggest that short N-terminal CLIP fragment(s) may represent endogenous hypnogenic factor(s) involved in the regulation of paradoxical sleep.
ISSN: 0143-4179
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
× corresponding author
# (joint) last author

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