Value of health-related quality of life to predict disability course in multiple sclerosis
Visschedijk, MAJ × Uitdehaag, BMJ Klein, M van der Ploeg, E Collette, EH Vleugels, Luc Pfennings, LEMA Hoogervorst, ELJ van der Ploeg, HM Polman, CH #
Lippincott williams & wilkins
Neurology vol:63 issue:11 pages:2046-2050
Objective: To determine the value of health-related quality of life (HRQoL) to predict change in disability status in patients with multiple sclerosis (MS). Methods: Over a 5-year period, data were collected on HRQoL ( Medical Outcomes Study Short Form-36 Health Survey) and disability status ( Expanded Disability Status Scale) from a heterogeneous group of 81 Dutch-speaking patients with MS. Results: Multivariate logistic regression analysis showed that HRQoL in the domains of Physical Functioning and Role - Physical Functioning is a significant predictor of change in disability status. Conclusions: A patient's subjectively perceived health-related quality of life may not be only a clinically and psychosocially meaningful outcome per se but may also be a predictor of objective outcomes such as change in disability status over a substantial period of time.