Title: Increased thromboxane formation in diabetic pregnancy as a possible contributor to preeclampsia
Authors: Van Assche, Frans Andre ×
Spitz, Bernard
Hanssens, Myriam
Van Geet, Christel
Arnout, Jozef
Vermylen, Jozef #
Issue Date: Feb-1993
Series Title: American journal of obstetrics and gynecology vol:168 issue:1 Pt 1 pages:84-7
Abstract: OBJECTIVE: Because pregnant women with diabetes have an increased risk of preeclampsia, we tested the hypothesis that urinary excretion of thromboxane metabolites is increased in diabetic pregnancies without evidence of preeclampsia at the time of testing. STUDY DESIGN: Urinary excretion of thromboxane A2 metabolites (either 2,3-dinor-thromboxane B2 or 11-dehydro-thromboxane B2) was measured in 24 type I pregnant diabetic individuals and in 20 women with normal pregnancies between 28 and 32 weeks' gestation. RESULTS: The amount of 2,3-dinor-thromboxane B2 and 11-dehydro-thromboxane B2 in the urine of pregnant women with diabetes (1727 +/- 415 and 827 +/- 276 pg/mg creatinine) was significantly higher than in women with normal pregnancies (638 +/- 218 and 178 +/- 145 pg/mg creatinine) (p < 0.002 and p < 0.001). CONCLUSION: Our findings support a role for thromboxane in the pathogenesis of preeclampsia.
ISSN: 0002-9378
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Section Woman - Miscellaneous (-)
Pediatric Hematology & Oncology Section (-)
Pathophysiology of Pregnancy Section (-)
Biomedical Sciences Group Management - miscellaneous
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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