Archives internationales de pharmacodynamie et de thérapie vol:276 issue:1 pages:28-34
Experiments were performed to evaluate the effects of BM 13.177 on vascular smooth muscle. Rabbit femoral arteries were mounted for isometric tension recording and made to contract with the endoperoxide analogues U44064 and U46619, prostaglandin F2 alpha and E2, norepinephrine, serotonin, histamine and ATP in the absence and in the presence of BM 13.177. This compound (7 X 10(-5)M) inhibited contractions to the endoperoxide analogues and did not affect or slightly potentiated contractions induced with the other agonists except for those evoked with prostaglandin F2 alpha, which tended to be slightly inhibited. In 2 out of 5 unstimulated preparations tested, BM 13.177 at 7 X 10(-6) and 7 X 10(-5)M caused small contractions. It is suggested that BM 13.177 is a selective thromboxane A2 receptor antagonist in vascular smooth muscle.