Title: Synthesis and anti-HIV evaluation of the novel 2-(m-chlorobenzyl)-4-substituted-7-methyl-1,1,3-trioxo-pyrazolo[4,5-e] [1,2,4]thiadiazines
Authors: Yan, Ren-Zhang ×
Liu, Xin-Yong
Xu, Wen-Fang
Pannecouque, Christophe
Witvrouw, Myriam
De Clercq, Erik #
Issue Date: Nov-2006
Series Title: Archives of pharmacal research vol:29 issue:11 pages:957-62
Abstract: A novel series of 2-(m-Chlorobenzyl)-4-substituted-1, 1, 3-trioxo-2H, 4H-pyrazolo[4, 5-e][1, 2, 4] thiadiazines (7a-k) were synthesized, and evaluated for their anti-HIV replication in MT-4 cell cultures. Compound (7a) showed activity against HIV-1-induced cytopathicity, with an EC50 value of 45.6 microM, but none of the compounds exhibited inhibitory activity against HIV-2.
ISSN: 0253-6269
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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