Author:

Keywords:

synaptic transmission, cerebral-cortex, neurons, receptors, induction, release, invitro, brain, gaba, activation, Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, Neurosciences, Neurosciences & Neurology, SYNAPTIC TRANSMISSION, CEREBRAL-CORTEX, NEURONS, RECEPTORS, INDUCTION, RELEASE, INVITRO, BRAIN, GABA, ACTIVATION, Animals, Anti-Anxiety Agents, Evoked Potentials, Hippocampus, Indoles, Long-Term Potentiation, Male, Meglumine, Pyramidal Cells, Rats, Rats, Wistar, Sincalide, Theta Rhythm, 0601 Biochemistry and Cell Biology, 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery, 3202 Clinical sciences, 3209 Neurosciences, 5202 Biological psychology

Abstract:

The effects of bath-applied sulphated cholecystokinin octapeptide (CCK-8S; 500 nM) and the selective CCKB receptor antagonist PD 135158 (1 mu M) on the induction and maintenance of an 'unsaturated' long-term potentiation (LTP) were examined using recordings of field excitatory postsynaptic potentials (fEPSP) and population spikes (PS) in the hippocampal CA1 region of the rat. LTP was induced by a single theta-pulse stimulation (10 pulses at 7 Hz) of the Schaffer collateral-commissural pathway.