Title: Infradian rhythms of alanine aminopeptidase excretion during gentamicin therapy
Authors: Balschun, Detlef ×
Burchardt, U
Klagge, M
Stein, W #
Issue Date: Dec-1991
Publisher: Walter de gruyter & co
Series Title: European journal of clinical chemistry and clinical biochemistry vol:29 issue:12 pages:783-786
Abstract: Urinary excretion of alanine aminopeptidase (EC was examined in 30 patients (22 women, 8 men, range 38-81 years; mean age 55.4) receiving gentamicin in a therapeutic dosage, which was based on the monitored blood creatinine concentration. In general, therapy lasted 10 days. The excretion of 24 individuals displayed significant infradian rhythms with periods between 2.2 and 8.1 days. In 10 of these 24 patients (42%) a circaseptan period was detected. The high portion of circaseptan rhythms might have been induced by the detrimental effects of gentamicin on the proximal tubule and the resulting processes of reconstitution.
ISSN: 0939-4974
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
× corresponding author
# (joint) last author

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