Title: BM 13.177, a selective blocker of platelet and vessel wall thromboxane receptors, is active in man
Authors: Gresele, P ×
Deckmyn, Hans
Arnout, Jozef
Lemmens, J
Janssens, W
Vermylen, Jozef #
Issue Date: Jun-1984
Series Title: Lancet vol:1 issue:8384 pages:991-4
Abstract: BM 13.177, a sulphonamide derivative, prevented platelet aggregation by thromboxane A2 in vitro and selectively inhibited contraction of isolated rabbit femoral arteries induced by two stable endoperoxide analogues. In a double-blind placebo-controlled study, oral BM 13.177 inhibited platelet aggregation induced by arachidonic acid, low dose collagen, and the two stable endoperoxide analogues, and slightly prolonged the bleeding time. Generation of thromboxane or of other prostaglandins was not affected. No side-effects were seen. BM 13.177 appears selectively and safely to block platelet and vessel wall thromboxane receptors and should be useful in elucidating the role of thromboxane A2 in disease.
ISSN: 0140-6736
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Chemistry, Campus Kulak Kortrijk
Biomedical Sciences Group Management - miscellaneous
Faculty of Medicine - miscellaneous
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
Molecular and Vascular Biology
× corresponding author
# (joint) last author

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