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Title: "Lupus" anticoagulant and inhibition of prostacyclin formation in patients with repeated abortion, intrauterine growth retardation and intrauterine death
Authors: Carreras, L O ×
Vermylen, Jozef
Spitz, Bernard
Van Assche, Frans Andre #
Issue Date: Nov-1981
Publisher: British Journal of Obstetrics and Gynaecology
Series Title: British Journal of Obstetrics and Gynaecology vol:88 issue:9 pages:890-4
Abstract: We discovered a "lupus' anticoagulant in 2 out of 42 women with a history of repeated abortions, intrauterine growth retardation and intrauterine death of unknown origin. The "lupus' anticoagulant was detected by an abnormal dilute tissue thromboplastin assay(prothrombin time performed with dilute thromboplastin). The production of prostacyclin by fresh or exhausted rings of rat aorta was decreased by the plasma of one of these two patients with a "lupus' anticoagulant. In view of the increasing evidence for a physiological role of prostacyclin in pregnancy and fetal life, we suggest that an inhibition of prostacyclin production could compromise fetal outcome.
ISSN: 0306-5456
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Section Woman - Miscellaneous (-)
Pathophysiology of Pregnancy Section (-)
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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