Title: Chemokines: A superfamily of chemotactic cytokines
Authors: Sozzani, S ×
Locati, M
Allavena, P
Van Damme, Jozef
Mantovani, A #
Issue Date: Jul-1996
Publisher: Springer verlag
Series Title: International journal of clinical & laboratory research vol:26 issue:2 pages:69-82
Abstract: Chemokines are a bipartite family of chemotactic proteins that bear the structural hallmark of four cysteine residues, the first two of which are in tandem. The spectrum of action of chemokines encompasses a large number of leukocyte populations, including monocytes, granulocytes, lymphocytes, NK and dendritic cells. Although the spectrum of action of chemokines largely overlaps? clear differences are still present. Chemokines play an important role in the recruitment of leukocytes at the site of inflammation, allergic reaction and tumors. Available information on receptor usage by MCP-1 and related chemokines and signal transduction pathways is reviewed. The better understanding of signaling mechanisms will provide a new basis for the development of therapeutic strategies.
ISSN: 0940-5437
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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