Title: Immunology of factor VIII inhibitors
Authors: Saint-Remy, Jean-Marie # ×
Issue Date: Jul-2002
Series Title: Seminars in thrombosis and hemostasis vol:28 issue:3 pages:265-8
Abstract: Why some patients with hemophilia A produce inhibitory antibodies is not known. However, many new findings both in the mechanisms of immune tolerance and in the understanding of the mechanisms by which antibodies interact with the factor VIII molecule are converging toward an integrated picture of what tolerance to factor VIII represents. The latter results from a subtle equilibrium among all partners of the immune system that is actively maintained. Circumstances under which such an equilibrium is disrupted are now better understood. The anti-factor VIII response can now be analyzed at the clonal level (both B and T levels), which allows us to test a number of hypotheses on both the prevention and the treatment of factor VIII inhibitors.
ISSN: 0094-6176
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science