Title: Learned defense response to hypoxia in newborn mice
Authors: Bollen, Bieke ×
Bouslama, Myriam
Matrot, Boris
D'Hooge, Rudi
Van den Bergh, Omer
Gallego, Jorge #
Issue Date: Jun-2007
Publisher: Elsevier ireland ltd
Series Title: Neuroscience Letters vol:420 issue:3 pages:268-272
Abstract: In newborns, hypoxia elicits defensive behaviors including awakening from sleep, body movements and crying. An inability to produce this defense response is a risk factor for sudden infant death syndrome and other respiratory control disorders. In this study, we examined the possibility that the defense response to hypoxia in newborns is partly determined by early exposure to hypoxia. We explored this possibility in 6-day-old mice, which resemble human preterm infants of approximately 25-30 weeks' gestational age. Ultrasonic vocalizations (USVs) were recorded as a marker for the defense response to hypoxia. In a conditioning experiment, newborn mice were exposed to two artificial odors (conditioned stimuli, CS). For acquisition (two trials), pups were exposed to one odor (CS+) in a hypoxic gas mixture (10% O-2, which was the unconditioned stimulus, US) and to another odor (CS-) in air. Then, the pups were exposed to each odor while breathing air. Newborn mice produced significantly more USVs when exposed to the odor previously paired with hypoxia than to the control odor. Thus, associative learning may shape the defense response to hypoxia in newborns. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
ISSN: 0304-3940
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
Health Psychology
× corresponding author
# (joint) last author

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