Title: Selective regulation of arterial branching morphogenesis by synectin
Authors: Chittenden, Thomas W
Claes, Filip
Lanahan, Anthony A
Autiero, Monica
Palac, Robert T
Tkachenko, Eugene V
Elfenbein, Arye
Ruiz de Almodovar, Carmen
Dedkov, Eduard
Tomanek, Robert
Li, Weiming
Westmore, Michael
Singh, Jai Pal
Horowitz, Arie
Mulligan-Kehoe, Mary Jo
Moodie, Karen L
Zhuang, Zhen W
Carmeliet, Peter
Simons, Michael #
Issue Date: Jun-2006
Series Title: Developmental cell vol:10 issue:6 pages:783-95
Abstract: Branching morphogenesis is a key process in the formation of vascular networks. To date, little is known regarding the molecular events regulating this process. We investigated the involvement of synectin in this process. In zebrafish embryos, synectin knockdown resulted in a hypoplastic dorsal aorta and hypobranched, stunted, and thin intersomitic vessels due to impaired migration and proliferation of angioblasts and arterial endothelial cells while not affecting venous development. Synectin(-/-) mice demonstrated decreased body and organ size, reduced numbers of arteries, and an altered pattern of arterial branching in multiple vascular beds while the venous system remained normal. Murine synectin(-/-) primary arterial, but not venous, endothelial cells showed decreased in vitro tube formation, migration, and proliferation and impaired polarization due to abnormal localization of activated Rac1. We conclude that synectin is involved in selective regulation of arterial, but not venous, growth and branching morphogenesis and that Rac1 plays an important role in this process.
ISSN: 1534-5807
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Animal Physiology and Neurobiology Section - miscellaneous
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
# (joint) last author

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