SIP1 (Smad interacting protein 1) and delta EF1 (delta-crystallin enhancer binding factor) are structurally similar transcriptional repressors - A current survey of their functions and mechanisms of action in transforming growth factor-beta signalling
Journal of Bone and Joint Surgery. American Volume vol:83A pages:S40-S47
Background: Smad proteins are intracellular mediators of transforming growth factor-beta (TGF beta) signalling that regulate gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. One of these, Smad interacting protein 1 (SIP1), is a novel two-handed zinc-finger protein that displays strong similarity with the transcriptional repressor delta -crystallin enhancer binding factor (delta EF1). Here, we summarize what is known about the mechanism of action of both proteins and their role in vertebrate embryogenesis. Our data are discussed together with the present knowledge on other zinc-finger containing Smad interacting proteins.