Title: Role of the fibrinolytic and matrix metalloproteinase systems in development of adipose tissue
Authors: Christiaens, Valerie ×
Lijnen, Roger #
Issue Date: Dec-2006
Publisher: Swets & Zeitlinger
Series Title: Archives of Physiology and Biochemistry vol:112 issue:4-5 pages:254-259
Abstract: Obesity is a common disorder and related diseases such as diabetes, atherosclerosis, hypertension, cardiovascular disease and cancer are a major cause of mortality and morbidity in Western-type societies. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. The fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems cooperate in these processes. A nutritionally induced obesity model in transgenic mice has been used extensively to study the role of the fibrinolytic and MMP systems in the development of obesity. These studies support a role of both systems in adipogenesis and obesity; the role of specific members of these families, however, remains to be determined.
ISSN: 1381-3455
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Laboratory of Computational Biology
× corresponding author
# (joint) last author

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