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Title: MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum
Authors: Taymans, Jean-Marc ×
Cruz, Catarina
Lesage, Anne
Leysen, Josée E
Langlois, Xavier #
Issue Date: Jan-2005
Series Title: Neuroreport vol:16 issue:2 pages:159-62
Abstract: The present report examines the effects of acute NMDA antagonism on Regulator of G Protein Signaling 2 (RGS2) expression and adenylyl cyclase sensitivity in the rat striatum. MK-801 and phencyclidine rapidly down-regulate RGS2 mRNA. The down-regulation of RGS2 by MK-801 was dose dependent and transient. Because previous reports showed that RGS2 attenuates activity of adenylyl cyclase, RGS2 protein level and sensitivity of adenylyl cyclase to forskolin was tested 2 h after administration of MK-801 (1 mg/kg). In striatal membranes of these rats, RGS2 protein level was 17% lower and forskolin-stimulated cAMP production 38% higher than in controls. These findings reveal a cross-talk between NMDA receptors and adenylyl cyclase and suggest a general cross-talk mechanism by which RGS proteins transcriptionally regulated by ionotropic receptors can alter signaling properties of metabotropic receptors.
URI: 
ISSN: 0959-4965
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group for Neurobiology and Gene Therapy
× corresponding author
# (joint) last author

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