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Title: The Partec CyFlow Counter (R) could provide an option for CD4+T-cell monitoring in the context of scaling-up antiretroviral treatment at the district level in Malawi
Authors: Fryland, M ×
Chaillet, P
Zachariah, R
Barnaba, A
Bonte, Lutgart
Andereassen, R
Charrondiere, S
Teck, R
Didakus, O #
Issue Date: Oct-2006
Publisher: Royal soc tropical medicine
Series Title: Transactions of the royal society of tropical medicine and hygiene vol:100 issue:10 pages:980-985
Abstract: A study was conducted in rural Malawi to verify (a) whether the Partec CyFtow Counter((R)) for CD4+ T-cell lymphocyte counting in HIV-positive individuals could be introduced into a district hospital. laboratory and (b) whether it would produce CD4 counts of acceptable quality. CD4+ cell, counting was performed using the Partec CyFtow Counter and the results were compared with a reference method (FACsCount). A total of 311 blood samples were analysed and the correlation coefficient for the CyFlow Counter was 0.92 (95% CI 0.89-0.95). Mean CD4 counts using the Partec and the reference methods were 308.2cells/mu l and 316.9cells/mu l, respectively. The mean difference in CD4 count values was -8.68cells/mu l (95% CI -18.8 to 1.4). Mean intra-run variation was -6.84cells/mu l (95% CI -12.9 to 0.79). In the district laboratory setting, the instrument could accommodate up to 75 blood samples per technician per day. After being trained, local laboratory staff found the CyFlow Counter procedures simple to run and the instrument easy to manipulate. The Partec CyFtow Counter produces sufficiently reliable results and the instrument appears robust under field conditions. It could provide a new option for introducing routine CD4+ cell monitoring at the district level. in the context of scaling-up antiretroviral. therapy in Malawi. (c) 2006 Royal. Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
URI: 
ISSN: 0035-9203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Onderzoeksgroep psychodiagnostiek en psychopathologie (-)
× corresponding author
# (joint) last author

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