Title: Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
Authors: Stalmans, Ingeborg ×
Ng, Yin-Shan
Rohan, Richard
Fruttiger, Marcus
Bouché, Ann
Yuce, Ali
Fujisawa, Hajime
Hermans, Bart
Shani, Moshe
Jansen, Alexandra
Hicklin, Dan
Anderson, David J
Gardiner, Tom
Hammes, Hans-Peter
Moons, Lieve
Dewerchin, Mieke
Collen, Desire
Carmeliet, Peter
D'Amore, Patricia A #
Issue Date: Feb-2002
Series Title: Journal of Clinical Investigation vol:109 issue:3 pages:327-336
Abstract: The murine VEGF gene is alternatively transcribed to yield the VEGF(120), VEGF(164), and VEGF(188) isoforms, which differ in their potential to bind to heparan sulfate and neuropilin-1 and to stimulate endothelial growth. Here, their role in retinal vascular development was studied in mice selectively expressing single isoforms. VEGF(164/164) mice were normal, healthy, and had normal retinal angiogenesis. In contrast, VEGF(120/120) mice exhibited severe defects in vascular outgrowth and patterning, whereas VEGF(188/188) mice displayed normal venular outgrowth but impaired arterial development. It is noteworthy that neuropilin-1, a receptor for VEGF(164), was predominantly expressed in retinal arterioles. These findings reveal distinct roles of the various VEGF isoforms in vascular patterning and arterial development in the retina.
ISSN: 0021-9738
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Animal Physiology and Neurobiology Section - miscellaneous
Research Group Ophthalmology
Vesalius Research Centre (-)
Animal Research Center
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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