Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Oncology, Adolescent, Adult, Age Factors, Aged, Child, Female, France, Graves Disease, Humans, Hyperthyroidism, Male, Middle Aged, Neoplasm Metastasis, Neoplasms, Radiation-Induced, Registries, Sex Factors, Thyroid Neoplasms, Oncology & Carcinogenesis

Abstract:

Between 1967 and 1984, 600 cases of clinically diagnosed thyroid carcinoma were collected in an area (Champagne-Ardenne) of about 1,500,000 inhabitants. During this period, the complete collection of the cases was progressively ensured by involving all the general practitioners and by creating a cooperative multidisciplinary group. The collected data were sex, age at diagnosis, histological classification and clinical extension in TNM system. We found 19 patients with previous neck irradiation. Thyroid cancer was diagnosed in association with thyrotoxicosis in 36 patients: 13 Graves disease and 23 nodular hyperthyroidism. Incidence rates were estimated on a well defined population of two districts (850,000 inhabitants) and limited to the last four years. The following results were obtained: incidence 4.3/100,000/year, age-specific incidence progressively increasing up to a value of 10/000,000/year in the course of the fifth decade. Sex-ratio was 0.26.