Title: Diet-induced obesity in gravid rats engenders early hyperadiposity in the offspring
Authors: Caluwaerts, Silvia ×
Lambin, Suzan
van Bree, Rita
Peeters, Herman
Vergote, Ignace
Verhaeghe, Johan #
Issue Date: Oct-2007
Publisher: W b saunders co-elsevier inc
Series Title: Metabolism: Clinical and Experimental vol:56 issue:10 pages:1431-1438
Abstract: Exposure to a dysmetabolic in utero environment may be one of the mechanisms to explain why individuals with high birth weight are more likely to remain overweight. We explored this hypothesis in an animal model of diet-induced obesity (DIO). We studied adipose tissue development and glucose tolerance in the offspring of rat dams fed a diet rich in milk and sugar from early adulthood until day (d) 2 postpartum. This diet promoted body weight, (BW) gain and was previously shown to produce insulin resistance and gestational glucose intolerance. The DIO offspring showed a higher BW in early life (between d7 and d35), with a maximum of 1 SD above the mean BW of controls; however, BW in DIO offspring after d35 was comparable with that of controls. Neonatal DIO offspring also showed larger fat depots, adipocyte hypertrophy (P <= .001), and more than 2-fold increased tumor necrosis factor alpha messenger RNA levels in subcutaneous adipose tissue (P < .05). In addition, they displayed a higher peak glucose response to a glucose challenge (P < .05). In postpubertal (d56) and adult (d98) offspring, we found differences in fat mass and distribution and glucose tolerance relating to the offspring's sex but not the maternal diet. In conclusion, DIO during pregnancy results in hyperadiposity and reduced glucose tolerance only in their neonatal/weanling but not postpubertal offspring. Future research should disclose whether these early-life effects are reactivated in conditions of heightened insulin resistance. (c) 2007 Elsevier Inc. All rights reserved.
ISSN: 0026-0495
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Pathophysiology of Pregnancy Section (-)
× corresponding author
# (joint) last author

Files in This Item:
File Status SizeFormat
Metabolism2007.pdf Published 425KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science