Title: Increased microvascular permeability in vivo in response to intradermal injection of neutrophil-activating protein (NAP-2) in rabbit skin
Authors: Van Osselaer, N ×
Van Damme, Jozef
Rampart, M
Herman, A G #
Issue Date: Jan-1991
Publisher: Amer soc investigative pathology, inc
Series Title: American Journal of Pathology vol:138 issue:1 pages:23-7
Abstract: Neutrophil-activating protein-2 (NAP-2), an NH2- terminally processed form of the platelet-release product beta thromboglobulin (beta-TG), was purified to homogeneity from stimulated human blood leukocytes. In the presence of a vasodilator substance (PGE2, CGRP) picomolar (pmol/l) amounts of NAP-2 induced neutrophil accumulation and plasma leakage on intradermal injection in rabbit skin, whereas the longer forms, beta-TG itself and connective tissue-activating peptide III (CTAP-III), had no such effect. NAP-2-induced increase in microvascular permeability was neutrophil dependent and fast in onset, with a half-life of 65 to 75 minutes, comparable to that previously reported for the structural-related neutrophil-activating protein/1interleukin-8 (NAP-1/IL-8). However NAP-2 showed a lower potency in that more protein was needed to provoke skin reactivity. Nevertheless the finding that a platelet release product can elicit neutrophil-mediated inflammation further narrows the gap between thrombotic events and inflammatory disorders.
ISSN: 0002-9440
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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