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Title: Dermorphin sequence with high delta-affinity by fixing the phe side-chain to trans at alpha-1
Authors: Tourwe, D × Verschueren, Kristin Vanbinst, G Davis, P Porreca, F Hruby, Vj #
Issue Date: Oct-1992
Publisher: Pergamon-elsevier science ltd
Series Title: Bioorganic & medicinal chemistry letters vol:2 issue:10 pages:1305-1308
Abstract: The Phe sidechain in dermorphin was fixed into the trans conformation by linking the aromatic ring to the Gly nitrogen through a methylene bridge. The compound has high mu- and delta-opioid activities.
Publication status: published
KU Leuven publication type: IT
Appears in Collections: Molecular Genetics Section (-)
× corresponding author
# (joint) last author
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