Title: Interleukin-4 down-regulates the expression of CD14 and the production of interleukin-6 in acute myeloid leukemia cells
Authors: Jansen, J H ×
Fibbe, W E
Wientjens, G J H M
Van Damme, Jozef
Landegent, J E
Willemze, R
Kluin-Nelemans, J C #
Issue Date: Dec-1991
Publisher: Mary ann liebert inc publ
Series Title: Lymphokine and cytokine research vol:10 issue:6 pages:457-61
Abstract: On normal monocytes, interleukin 4 (IL-4) down-regulates the production of several proteins that are produced in response to bacterial cell wall lipopolysaccharides (LPS), among others IL-6. In addition, IL-4 was shown to down-regulate the expression of the monocytic differentiation marker CD14, recently identified as a receptor for LPS. Since (autocrine) IL-6 is possibly involved in the proliferation and differentiation of acute myeloid leukemia cells with myelomonocytic differentiation (AML-M4/M5), we studied the effects of IL-4 on IL-6 production and CD14 expression by these cells. We found that IL-4 down-regulates both the expression of CD14 (n = 6) and the production of IL-6 (n = 9) in AML cells. Using Northern blot analysis, we found that IL-4 down-regulates the level of steady-state mRNA for both CD14 (two of three cases tested) and IL-6 (three cases tested).
ISSN: 0277-6766
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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