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Title: Hepatitis C virus genotypes in Belgian hemophiliacs
Authors: Sheng, L ×
Willems, M
Peerlinck, Kathelijne
Vermylen, Jozef
Yap, Sing Hiem #
Issue Date: Jul-1995
Series Title: Journal of medical virology vol:45 issue:2 pages:211-4
Abstract: Hemophiliacs who have been exposed to unheated and/or dry heated pooled clotting factor concentrates are at a high risk of chronic hepatitis C. Serum HCV-RNA was measured by reverse transcriptase-polymerase chain reaction (RT-PCR) technique in 58 hemophiliacs positive for anti-HCV antibodies, HCV-RNA was detected in 55 patients. Based on the results of PCR positivity, HCV genotyping was carried out using genotype specific probes and the dot blot hybridization assay: 2 patients were found to be infected with type 1a (3.6%), 31 patients with type 1b (56.4%), 8 patients with type 2 (14.6%), 6 patients with type 3 (10.9%), 1 patient with type 4, and 7 patients with double infection (12.7%). As compared to a control group of 105 nonhemophilia patients with chronic hepatitis C, HCV genotype 1b was found predominant in both groups. However, double infection with two HCV types as well as a relatively high prevalence of infection with type 2 and type 3 were found in hemophiliacs.
ISSN: 0146-6615
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Hepatology
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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