Title: Roles of urokinase type plasminogen activator in a brain stab wound
Authors: Kataoka, K ×
Asai, T
Taneda, M
Ueshima, S
Matsuo, O
Kuroda, R
Kawabata, A
Carmeliet, Peter #
Issue Date: Feb-2001
Series Title: Brain Research vol:887 issue:1 pages:187-90
Abstract: Urokinase type plasminogen activator (uPA) may influence brain pathophysiology after injury. We studied disruption of the blood-brain barrier (BBB) and changes in the vasculature after a brain stab wound in uPA-deficient, uPA receptor-deficient, and PA inhibitor-1 (PAI-1) deficient mice. The extravasation of immunoglobulin was greater in PAI-1 deficient mice; less pronounced in uPA-deficient mice; similar to controls in uPA receptor-deficient mice. Vasculatures in the wound proliferated in PAI-1 deficient mice. Our study shows that uPA affects BBB disruption. PA enhances angiogenesis after brain injury.
ISSN: 0006-8993
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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