Roles of urokinase type plasminogen activator in a brain stab wound
Kataoka, K × Asai, T Taneda, M Ueshima, S Matsuo, O Kuroda, R Kawabata, A Carmeliet, Peter #
Brain Research vol:887 issue:1 pages:187-90
Urokinase type plasminogen activator (uPA) may influence brain pathophysiology after injury. We studied disruption of the blood-brain barrier (BBB) and changes in the vasculature after a brain stab wound in uPA-deficient, uPA receptor-deficient, and PA inhibitor-1 (PAI-1) deficient mice. The extravasation of immunoglobulin was greater in PAI-1 deficient mice; less pronounced in uPA-deficient mice; similar to controls in uPA receptor-deficient mice. Vasculatures in the wound proliferated in PAI-1 deficient mice. Our study shows that uPA affects BBB disruption. PA enhances angiogenesis after brain injury.