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Title: Thromboembolic complications and haemostatic changes in cyclosporin-treated cadaveric kidney allograft recipients
Authors: Vanrenterghem, Yves ×
Roels, L
Lerut, Antoon
Gruwez, Jacques
Michielsen, Paul
Gresele, P
Deckmyn, Hans
Colucci, M
Arnout, Jozef
Vermylen, Jozef #
Issue Date: Jun-1985
Publisher: LANCET LTD
Series Title: Lancet vol:1 issue:8436 pages:999-1002
Abstract: The incidence of thromboembolic complications was compared retrospectively in 90 cadaveric kidney allograft recipients treated with cyclosporin and low-dose steroids and the same number of cadaveric kidney allograft recipients treated with azathioprine, antilymphocyte globulin, and high-dose steroids. In the cyclosporin group, 17 thromboembolic complications occurred in 13 patients: 10 pulmonary emboli, 1 renal vein thrombosis, 3 deep vein thromboses, and 3 haemorrhoidal thromboses. In the azathioprine group, the only thromboembolic complication was 1 episode of superficial thrombophlebitis. Haemostatic tests in cyclosporin-treated and azathioprine-treated patients and normal subjects (10 in each group) showed increased concentrations of factor VIII C, fibrinogen, antithrombin III, and protein C in the cyclosporin-treated patients. Adenosine-5'-diphosphate-induced platelet aggregation was also significantly enhanced in the cyclosporin group. The effect of cyclosporin on haemostasis may predispose to thromboembolic complications.
ISSN: 0140-6736
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Nephrology
Molecular and Vascular Biology
Thoracic Surgery
Chemistry, Campus Kulak Kortrijk
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
Biomedical Sciences Group Management - miscellaneous
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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