Title: Passage of inhaled particles into the blood circulation in humans
Authors: Nemmar, Abderrahim
Hoet, Peter
Vanquickenborne, B
Dinsdale, D
Thomeer, Maarten
Hoylaerts, Marc
Vanbilloen, H
Mortelmans, Luc
Nemery, Benoit # ×
Issue Date: Jan-2002
Series Title: Circulation vol:105 issue:4 pages:411-4
Abstract: BACKGROUND: Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. METHODS AND RESULTS: To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic circulation, we measured, in 5 healthy volunteers, the distribution of radioactivity after the inhalation of "Technegas," an aerosol consisting mainly of ultrafine (99m)Technetium-labeled carbon particles (<100 nm). Radioactivity was detected in blood already at 1 minute, reached a maximum between 10 and 20 minutes, and remained at this level up to 60 minutes. Thin layer chromatography of blood showed that in addition to a species corresponding to oxidized (99m)Tc, ie, pertechnetate, there was also a species corresponding to particle-bound (99m)Tc. Gamma camera images showed substantial radioactivity over the liver and other areas of the body. CONCLUSIONS: We conclude that inhaled (99m)Tc-labeled ultrafine carbon particles pass rapidly into the systemic circulation, and this process could account for the well-established, but poorly understood, extrapulmonary effects of air pollution.
ISSN: 0009-7322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Occupational, Environmental and Insurance Medicine (-)
Nuclear Medicine & Molecular Imaging
Environment and Health - miscellaneous
Molecular and Vascular Biology
× corresponding author
# (joint) last author

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