Title: Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
Authors: Li, Xuri ×
Tjwa, Marc
Moons, Lieve
Fons, Pierre
Noel, Agnes
Ny, Annelii
Zhou, Jian Min
Lennartsson, Johan
Li, Hong
Luttun, Aernout
Pontén, Annica
Devy, Laetitia
Bouché, Ann
Oh, Hideyasu
Manderveld, Ann
Blacher, Silvia
Communi, David
Savi, Pierre
Bono, Françoise
Dewerchin, Mieke
Foidart, Jean-Michel
Autiero, Monica
Herbert, Jean-Marc
Collen, Desire
Heldin, Carl-Henrik
Eriksson, Ulf
Carmeliet, Peter #
Issue Date: Jan-2005
Publisher: American Society for Clinical Investigation
Series Title: Journal of Clinical Investigation vol:115 issue:1 pages:118-127
Abstract: The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
ISSN: 0021-9738
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Animal Physiology and Neurobiology Section - miscellaneous
Vesalius Research Centre (-)
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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