Title: N-aminoimidazole (NAIM) derivatives inhibiting retroviral replication via a yet unidentified mode of action
Authors: Lagoja, Irene
Pannecouque, Christophe
Van Aerschot, Arthur
Witvrouw, Myriam
Debyser, Zeger
Balzarini, Jan
Herdewijn, Piet ×
De Clercq, Erik #
Issue Date: Apr-2003
Series Title: Journal of Medicinal Chemistry vol:46 issue:8 pages:1546-1553
Abstract: The synthesis of a series of N-aminoimidazoles (NAIMs) with an uncommon spectrum of antiretroviral activity is described. From a group of 60 closely related molecules, we were able to subdivide the molecules in different groups based on their anti-HIV and anti-SIV activity in vitro: (i) molecules acting on a new, immediate postintegration step, (ii) molecules acting on both postintegration and HIV-1 reverse transcriptase (RT) as NNRTI, and (iii) molecules that mainly act at the HIV-1 RT according to an NNRTI-type mode of action.
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Laboratory of Virology and Chemotherapy (Rega Institute)
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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