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Title: Platelet ultrastructural and functional studies in myelodysplasia
Authors: Blockmans, Daniel Engelbert ×
Heynen, M J
Verhoef, Gregor
Vermylen, Jozef #
Issue Date: Aug-1995
Publisher: Académiai Kiado
Series Title: Haematologia vol:26 issue:3 pages:159-72
Abstract: We studied the platelets of 8 patients with myelodysplasia aged 49-77 years, using both ultrastructural and functional techniques. Five of the 8 patients were classified as having refractory anaemia, and 3 as refractory anaemia with excess of blasts (RAEB). Electron microscopically, the myelodysplastic patients had in addition to normal ones, platelets containing significantly less alpha-granules. In part of these hypogranular platelets, the dense tubular system was abundant, but in contrast with normal platelets, it was not dispersed between the other organelles, nor did it form a membrane complex with the open cannalicular system. From a functional point of view, collagen-induced shape change was the most frequently disturbed parameter: there was a total loss of collagen-induced shape change in 5 patients. In 2 patients, there was a complete lack of response to collagen in platelet-rich plasma (both shape change and aggregation); in one of them, there was also a total loss of adenosine triphosphate secretion in response to all inducers tested. After 4 years of follow-up, 5 patients had died, of whom 3 were RAEB patients. An initial complete absence of collagen-induced shape change was found in these 5 patients, while in the 3 patients who were still alive at the end of the follow-up period, collagen-induced shape change was normal in 2 and slightly diminished in one.
ISSN: 0017-6559
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Laboratory for Clinical Infectious and Inflammatory Disorders
Hematology Section (-)
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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